| Date | Location | Result | |
| 02/26/22 | Campus Center Gym | Jefferson 74, Holy Family 67 | Box score |
| 02/23/22 | Campus Center Gymnasium | Holy Family 76, Goldey-Beacom 37 | Box score |
| 02/21/22 | Campus Center Gym | Holy Family 74, Nyack 49 | Box score |
| 02/19/22 | Philadelphia, PA | USciences 61, Holy Family 51 | Box score |
| 02/09/22 | Wellness Center/Lakewood, N.J. | Georgian Court 71, Holy Family 62 (OT) | Box score |
| 02/01/22 | Campus Center Gym | Holy Family 73, Wilmington (Del.) 34 | Box score |
| 01/30/22 | Job Gymnasium/Rutherford, N.J. | Holy Family 56, Felician 51 | Box score |
| 01/26/22 | Sorgenti Arena, Philadelphia, Pa. | Chestnut Hill 68, Holy Family 62 | Box score |
| 01/23/22 | Campus Center Gym | Holy Family 71, Dominican (N.Y.) 59 | Box score |
| 01/20/22 | Philadelphia, PA | Holy Family 70, Jefferson 69 | Box score |
| 01/15/22 | Campus Center Gym | Holy Family 52, Bloomfield 39 | Box score |
| 01/11/22 | Wilmington, DE | Holy Family 61, Goldey-Beacom 52 | Box score |
| 01/08/22 | Caldwell, N.J.-Corino Court | Caldwell 68, Holy Family 57 | Box score |
| 01/05/22 | Campus Center Gym | USciences 65, Holy Family 39 | Box score |
| 01/02/22 | Drubner Center | Post 91, Holy Family 54 | Box score |
| 12/30/21 | East Stroudsburg, PA | East Stroudsburg 57, Holy Family 47 | Box score |
| 12/07/21 | Campus Center Gym | Holy Family 72, Georgian Court 61 | Box score |
| 12/04/21 | Newark, DE | Wilmington (DE) 69, Holy Family 64 | Box score |
| 12/01/21 | Philadelphia, PA | Chestnut Hill 66, Holy Family 63 | Box score |
| 11/28/21 | New Haven, CT | Southern Conn. St. 68, Holy Family 52 | Box score |
| 11/27/21 | Manchester, N.H. (Stoutenburgh Gym) | Holy Family 64, Saint Anselm 61 | Box score |
| 11/24/21 | Kutztown, PA | Kutztown 79, Holy Family 61 | Box score |
| 11/21/21 | Campus Center Gym | Holy Family 71, Shippensburg 64 | Box score |
| 11/19/21 | Campus Center Gym | Holy Family 65, Molloy 62 (OT) | Box score |
| 11/17/21 | Campus Center Gym | Holy Family 53, Bloomsburg 45 | Box score |
| 11/14/21 | Staten Island, NY | Holy Family 59, Staten Island 50 | Box score |
| 11/13/21 | College of Staten Island | Franklin Pierce University 68, Holy Family 57 | Box score |